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Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. Feldman HC, et al. Nat Chem Biol. 2021 Nov;17(11):1148-1156. doi: 10.1038/s41589-021-00852-0. Epub 2021 Sep 23. Nat Chem Biol. 2021. PMID: 34556859 Free PMC article.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Morita S, et al. Among authors: feldman hc. Cell Metab. 2017 Apr 4;25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018. Cell Metab. 2017. PMID: 28380378 Free PMC article.
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Morita S, et al. Among authors: feldman hc. Cell Metab. 2017 May 2;25(5):1207. doi: 10.1016/j.cmet.2017.04.026. Cell Metab. 2017. PMID: 28467938 Free article. No abstract available.